2016 – 2021


K. Falahkheirkhah, K. Yeh, S. Mittal, L. Pfister, and R. Bhargava “Deep learning-based protocols to enhance infrared imaging systems” Chemometrics and Intelligent Laboratory Systems (2021). [Special Issue]
Paper | DOI: 10.1016.j.chemolab.2021.104390

E. Zimmerman*, S. Mukherjee*, K. Falahkheirkhah, M. Gryka, A. Kajdacsy-Balla, W. Hasan, G. Giraud, F. Tibayan, J. Raman, and R. Bhargava “Detection and Quantification of Myocardial Fibrosis Using Stain-Free Spectroscopic Imaging” Archives of Pathology & Laboratory Medicine (2021). [*Joint First Author]
Paper | DOI: 10.5858/arpa.2020-0635-OA

Y. Phal, K. Yeh, and R. Bhargava “EXPRESS: Design Considerations for Discrete Frequency Infrared Microscopy Systems” Applied Spectroscopy (2021).
Paper | DOI: 10.1177/00037028211013372

S. Mittal, T. Wrobel, M. Walsh, A. Kajdacsy-Balla, and R. Bhargava “Breast cancer histopathology using infrared spectroscopic imaging: The impact of instrumental configurations” Clinical Spectroscopy (2021).
Paper | DOI: 10.1016/j.clispe.2021.100006

K. Falahkheirkhah, and R. Bhargava “Enhancing hyperspectral imaging” Nature Machine Intelligence (2021).
Paper | DOI: 10.1038/s42256-021-00336-9

S. Tiwari, A. Kajdacsy-Balla, J. Whiteley, G. Cheng, S. Hewitt, and R. Bhargava “INFORM: INFrared-based ORganizational Measurements of tumor and its microenvironment to predict patient survival” Science Advances (2021).
Paper | DOI: 10.1126/sciadv.abb8292


Y. Phal, K. Yeh, R. Bhargava “Concurrent Vibrational Circular Dichroism Measurements with Infrared Spectroscopic Imaging” Analytical Chemistry (2020).
Paper | DOI: 10.1021/acs.analchem.0c00323

L. Chen, S. Kenkel, P. Hsieh, M. Gryka, R. Bhargava “Freeform Three-Dimensionally Printed Microchannels via Surface-Initiated Photopolymerization Combined with Sacrificial Molding” Applied Materials & Interfaces (2020).
Paper | DOI: 10.1021/acsami.0c12158

M. Schnell, S. Mittal, K. Falahkheirkhah, A. Mittal, K. Yeh, S. Kenkel, A. Kadjacsy-Balla, P. Scott Carney, R. Bhargava “Infrared Optical Hybrid (IR-OH) Microscopy for Label-Free Histopathology” Frontiers in Optics (2020).
Paper | DOI: 10.1364/FIO.2020.FW7E.5

S. Kenkel, S. Mittal, R. Bhargava “Closed-loop atomic force microscope-infrared spectroscopic imaging for nanoscale imaging for nanoscale molecular characterization” Nature Communications (2020).
Paper | DOI: 10.1038/s41467-020-17043-5

S. Tiwari, T. Triulzi, S. Holton, V. Regondi, B. Paolini, E. Tagliabue, R. Bhargava “Infrared Spectroscopic Imaging Visualizes a Prognostic Extracellular Matrix-Related Signature in Breast Cancer” Scientific Reports (2020).
Paper | DOI: 10.1038/s41598-020-62403-2

Y. Phal, K. Yeh, R. Bhargava “Polarimetric infrared spectroscopic imaging using quantum cascade lasers” Advanced Chemical Microscopy for Life Science and Translational Medicine (2020).
Paper | DOI: 10.1117/12.2544392

S. Mittal, A. Balla, R. Bhargava “Deep Learning Models for Reliable Detection of the Intraductal Lesions of the Breast” Proceedings of Laboratory Investigation Volume 100, Issue Suppl1, Pages 1480-1481 [Conference Paper] Nature (2020).

M. Schnell, S. Mittal, K. Falahkheirkhah, A. Mittal, K. Yeh, S. Kenkel, R. Bhargava “All-digital histopathology by infrared-optical hybrid microscopy” Proceedings of the National Academy of Sciences 18 3388-3396 (2020).
Paper | DOI: 10.1073/pnas.1912400117

N. Schorr, M. Counihan, R. Bhargava, J. Rodríguez-López “Impact of Plasmonic Photothermal Effects on the Reactivity of Au Nanoparticle Modified Graphene Electrodes Visualized Using Scanning Electrochemical Microscopy” Analytical chemistry 92 3666-3673 (2020).
Paper | DOI: 10.1021/acs.analchem.9b04754

A. Tariq, Q. Hao, Q. Sun, DK. Singh, M. Jadaliha, Y. Zhang, N. Chetlangia, J. Ma, S. Holton, R. Bhargava, A. Lal, S. Prasanth, K. Prasanth “LncRNA-mediated regulation of SOX9 expression in basal subtype breast cancer cells” RNA 26 175-185 (2020).
Paper | DOI: 10.1261/rna.073254.119


Richard, R. McGee, A. Goenka, P. Mukherjee, R. Bhargava “On-demand Milifluidic Synthesis of Quantum Dots in Digital Droplet Reactors” Industrial & Engineering Chemistry Research 7 3730-3735 (2019).
Paper | DOI: 10.1021/acs.iecr.9b04230

S. Mittal, C. Stoean, A. Kajdacsy-Balla, R. Bhargava “Digital Assessment of Stained Breast Tissue Images for Comprehensive Tumor and Microenvironment Analysis” Frontiers in Bioengineering and Biotechnology 7 246 (2019).
Paper | DOI: 10.3389/fbioe.2019.00246

I. Srivastava, D. Sar, P. Mukherjee… R. Bhargava, D. Pan “Enzyme-catalysed biodegradation of carbon dots follows sequential oxidation in a time dependent manner” Nanoscale 11 8226-8236 (2019).
Paper | DOI: 10.1039/C9NR00194H

S. Berisha, M. Lotfollahi, J. Jahanipour, I. Gurcan, M. Walsh R. Bhargava, H. Van Nguyen, D. Mayerich “Deep learning for FTIR histology: leveraging spatial and spectral features with convolutional neural networks” Analyst 144 1642-1653 (2019).
Paper | DOI: 10.1039/C8AN01495G

I.L. Rasskazov, R. Singh, P.S. Carney, R. Bhargava “Extended Multiplicative Signal Correction for Infrared Microspectroscopy of Heterogeneous Samples with Cylindrical Domains” App. Spec (2019).
Paper | DOI: 10.1177/0003702819844528

S. Kenkel, R. Bhargava “Nanoscale imaging of biological samples with responsivity corrected atomic force microscopy-infrared (AFM-IR) spectroscopy” Proceedings of SPIE – The International Society for Optical Engineering Volume 10891, Article Number 108910A (2019).
[Conference Paper] | Paper

R. Singh, T.P. Wrobel, P. Mukherjee, M. Gryka, M. Kole, S. Harrison, R. Bhargava “Bulk Protein and Oil Prediction in Soybeans Using Transmission Raman Spectroscopy: A Comparison of Approaches to Optimize Accuracy” App. Spec In Press (2019).
Paper | DOI: 10.1177/0003702818815642

A. Holian, R.F. Hamilton Jr., S. Deb, K.L. Trout, Z. Wang R. Bhargava, S. Mitra “Lung deposition patterns of MWCNT vary with degree of carboxylation” Nanotoxicology 13:2, 143-159 (2019).
Paper | DOI: 10.1080/17435390.2018.15303922

P. Mukherjee, A. Ghosh, M.J. Lamborn, M.M. Monwar, J.S. Fodor, P.J. DesLauriers, R. Bhargava “Relating strain hardening moduli in high density polyethylene copolymers to anisotropic molecular deformation using infrared spectroscopic imaging” Polymer 172, 398-403 (2019).
Paper | DOI: 10.1016/j.polymer.2019.04.012

M.C. Gryka, T.J. Comi, R.A. Forsyth, P.M. Hadley, S. Deb R. Bhargava “Controlled dissolution of freeform 3D printed carbohydrate glass scaffolds in hydrogels using a hydrophobic spray coating” Add. Man26, 193-201 (2019).
Paper | DOI: 10.1016/j.addma.2018.12.014

S. Gupta, S. Mittal, A. Kajdacsy-Balla, R. Bhargava, C. Bajaj “A fully automated, faster noise rejection approach to increasing the analytical capability of chemical imaging for digital histopathology” PLOS ONE 14(4), e0205219 (2019).
Paper | DOI: 10.1371/journal.pone.0205219

S. Mittal, R. Bhargava “A comparison of mid-infrared spectral regions on accuracy of tissue classification” Analyst 144, 2635-2642 (2019).
Paper | DOI: 10.1039/C8AN01782D

K. Yeh, D. Lee, R. Bhargava “Multicolor Discrete Frequency Infrared Spectroscopic Imaging” Anal. Chem 91 (3), 2177-2185 (2019).
Paper | DOI: 10.1021/acs.analchem.8b04749


M.K. Gelber, G. Hurst, R. Bhargava “Freeform Assembly Planning” IEEE Transactions on Automation Science and Engineering, 1-15 (2018).
Paper | DOI: 10.1109/TASE.2018.2878670

E.K. Neumann, T.J. Comi, N. Spegazzini,…R. Bhargava, J.V. Sweedler “Multimodal Chemical Analysis of the Brain by High Mass Resolution Mass Spectrometry and Infrared Spectroscopic Imaging” Anal. Chem 90, (19), 11572-11580 (2018).
Paper | DOI: 10.1021/acs.analchem.8b02913

A. Ganguli, A Ornob,…R. Bhargava, A.M. Smith, F. Korari, R. Bashir “Pixelated spatial gene expression analysis from tissue” Nat. Comm. Lett 9, Article number: 202 (2018).
Paper | DOI: 10.1038/s41467-017-02623-9

M. Jadaliha, O. Gholamalamdari,…R. Bhargava, A. Lal, S.G. Prasanth, J. Ma, K.V. Prasanth “A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stabilit” PLoS Genetics 11, Article number: e1007802 (2018).
Paper | DOI: 10.1371/journal.pgen.1007802

S. Pahlow, K. Weber…R. Bhargava “Application of Vibrational Spectroscopy and Imaging to Point-of-Care Medicine: A Review” App. Spec. 72, 52-84 (2018).
Paper | DOI: 10.1177/0003702818791939

M.K. Gelber, G. Hurst, T.J. Comi, R. Bhargava “Model-guided design and characterization of a high-precision 3D printing process for carbohydrate glass” Add. Man. 22, 38-50 (2018).
Paper | DOI: 10.1016/j.addma.2018.04.026

S. Mittal, K. Yeh, L.S. Leslie, S. Kenkel, A. Kajdacsy-Balla R. Bhargava “Simultaneous cancer and tumor microenvironment subtyping using confocal infrared microscopy for all-digital molecular histopathology” PNAS 115, Issue 25, E5651-E5660 (2018).
Paper | DOI: 10.1073/pnas.1719551115

M.K. Gelber, G. Hurst, R. Bhargava “Freeform Direct-Write Assembly Planning” IEEE Tran. Auto. Sci. Eng. (2018)
Paper | DOI: arXiv:1801.00527

P. Mukherjee, A. Ghosh, N. Spegazzini, M.J. Lamborn, M.M. Monwar, P.J. DesLauriers, R. Bhargava “Relating Post-yield Mechanical Behavior in Polyethylenes to Spatially Varying Molecular Deformation Using Infrared Spectroscopic Imaging: Homopolymers” Macromolecules 51(10), 3836-3844 (2018).
Paper | DOI: 10.1021/acs.macromol.8b00363

K. Chrabaszcz, K. Kochan… R. Bhargava, K. Male, S. Chlopicki, K.M. Marzec “FT-IR- and raman-based biochemical profiling of the early stage of pulmonary metastasis of breast cancer in mice” Analyst 143, 2042-2050 (2018).
Paper | DOI: 10.1039/c7an01883e

R. Mankar, M.J. Walsh R. Bhargava, S. Prasad, D. Mayerich “Selecting optimal features from Fourier transform infrared spectroscopy for discrete-frequency imaging” Analyst 143, 1147-1156 (2018).
Paper | DOI: 10.1039/C7AN01888F

S. Kenkel, A. Mittal, S. Mittal R. Bhargava “Probe-sample interaction-independent Atomic Force Microscopy-Infrared (AFM-IR) spectroscopy: Towards robust nanoscale compositional mapping” Anal. Chem90, (15), 8845-8855 (2018).
Paper | DOI: 10.1021/acs.analchem.8b00823

T.P. Wrobel, R. Bhargava “Infrared Spectroscopic Imaging Advances as an Analytical Technology for Biomedical Sciences” Anal. Chem 90, 1444-1463 (2018).
Paper | DOI: 10.1021/acs.analchem.7b05330

I. Kang, A. Grant, M. Dinu, J. Jaques, L. Pfister, R. Bhargava, P.S. Carney “Agile optoelectronic fiber sources for hyperspectral chemical sensing from SWIR to LWIR” Proceedings of SPIE – The International Society for Optical Engineering Volume 10644, Article Number 106441E (2018). [Conference Paper]

I.L. Rasskazov, L. Wang, C.J. Murphy R. Bhargava, P.S. Carney “Plasmon-enhanced upconversion: Engineering enhancement and quenching at nano and macro scales” Optical Materials Express 8, 3787-3804 (2018).
Paper | DOI: 10.1364/OME.8.003787


A. Ghosh, P. Mukherjee, S. Deb R. Bhargava “Mapping Solvation Environments in Porous Metal–Organic Frameworks with Infrared Chemical Imaging” J. Phys. Chem. Lett 8, 5325-5330 (2017).
Paper | DOI: 10.1021/acs.jpclett.7b02104

I.L. Rasskazov, N. Spegazzini, P.S. Carney, R. Bhargava “Dielectric Sphere Clusters as a Model to Understand Infrared Spectroscopic Imaging Data Recorded from Complex Samples” Anal. Chem. 89, 10813-10818 (2017).
Paper | DOI: 10.1021/acs.analchem.7b02168

B.M. DeVetter, S. Kenkel, S. Mittal, R. Bhargava, T.P. Wrobel “Characterization of the structure of low-e substrates and consequences for IR transflection measurements” Vib. Spectrosc. 91, 119-127 (2017).
Paper | DOI: 10.1016/j.vibspec.2016.09.001

D.K. Singh, O. Gholamalamdari, X.L. Li, A. Chakraborty, Y. Zhang, S. Guang, S. Hashemikhabir, S. Tiwari, A. Thomas, V. Macias, A. Kadjacsy-Balla, R. Bhargava, S.C. Janga, J. Ma, S.G. Prasanth, A. Lal, K.V. Prasanth “PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes” Carcin. bgx062,(2017).
Paper | DOI: 10.1093/carcin/bgx062

N.D. Jackson, K.I. Tyler, Y. Li, W.-T. Chen, C. Liu, R. Bhargava “Keeping current: An update on the structure and evaluation of a program for graduate women interested in engineering Academia” ASEE Annual Conference and Expo (2017). [Conference Paper]

A.M Andrews, R. Bhargava, R. Kennedy, L. Li, J. Sweedler, “The Chemistry of Thought: The Role of the Measurement Sciences in Brain Research” Anal. Chem. 89, 4757 (2017).
Paper | DOI: 10.1021/acs.analchem.7b01364 [Editorial]

S. Berisha, T. van Dijk, R. Bhargava, P.S. Carney, D. Mayerich “BIM-Sim: Interactive Simulation of Broadband Imaging Using Mie Theory” Fron. Phys.: Opt. Phot. 5(FEB) 5 (2017).
Paper | DOI: 10.3389/fphy.2017.00005

M.K. Gelber, M.R. Kole, N. Kim, N. Aluru, R. Bhargava “Quantitative Chemical Imaging Within Non-Planar Microfluidics” Anal. Chem. 89, 1716-1723 (2017).
Paper | DOI: 10.1021/acs.analchem.6b03943

T.P. Wrobel, P. Mukherjee, R. Bhargava “Rapid visualization of macromolecular orientation by discrete frequency mid-infrared spectroscopic imaging” Analyst 142, 75-79 (2017).
Paper | DOI: 10.1039/C6AN01086E


T.Q. Doan, L.S. Leslie, S.Y. Kim, R. Bhargava, S.R. White, N. Sottos “Characterization of core-shell microstructure and self-healing performance of electrospun fiber coatings” Polymer 107, 263-272 (2016).
Paper | DOI: 10.1016/j.polymer.2016.10.062

F. Ostadhossein, S. K. Misra, P. Mukherjee, A. Ostadhossein, E. Daza, S. Tiwari, S. Mittal, M. Gryka, R. Bhargava, D. Pan “Breast Cancer Therapy: Defined Host–Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer” | Inside Front Cover Small 12, 5782 (2016).
Paper | DOI: 10.1002/smll.201670216

S. Tiwari, C. Hoke, V. Reddy, J. Raman, R. Bhargava “Translating infrared spectroscopic imaging for rapid analysis of biopsy samples using a discrete frequency approach” Anal. Chem. 88, 10183-10190 (2016).
Paper | DOI: 10.1021/acs.analchem.6b02754

P. Mukherjee, S.J. Lim, T. P. Wrobel, R. Bhargava,* A. M. Smith* “Measuring and predicting the internal structure of semiconductor nanocrystals through Raman spectroscopy” J. Am. Chem. Soc. 138, 10887-10896 (2016). [*joint corresponding authors]
Paper | DOI: 10.1021/jacs.6b03907

R. Bhargava, A. Madabhushi “Emerging themes in image informatics and molecular analysis for digital pathology” Ann. Rev. of Biomed. Eng. 18, 387-412 (2016).
Paper | DOI: 10.1146/annurev-bioeng-112415-114722

S. Misra, P. Mukherjee, H.-H. Chang, S. Tiwari, M. Gryka, R. Bhargava, D. Pan “Multi-functionality redefined with collodial carotene carbon nanoparticles for synchronized chemical imaging, enriched cellular uptake and therapy” Sci. Rep. 6, 29299 (2016).
Paper | DOI: 10.1038/srep29299

T.P. Wrobel, M.R. Kole, R. Bhargava “Emerging trends and opportunities in discrete-frequency infrared and Raman spectroscopic imaging” | Inside Front Cover Spectroscopy 31, 28-45 (2016).

J.T. Kwak, S. M. Hewitt, A. A. Kadjacsy-Balla, S. Sinha, R. Bhargava “Automated Prostate tissue referencing for cancer detection and diagnosis” BMC Bioinfo. 17, 227 (2016).
Paper | DOI: 10.1186/s12859-016-1086-6

M. Saha, I. Arun, B. Basak, S. Agarwal, R. Ahmed, S. Chatterjee, R. Bhargava, C. Chakraborty “Quantitative microscopic evaluation of mucin areas and its percentage in mucinous carcinoma of the breast using tissue histological images” Tissue and Cell 48, 256-273 (2016).
Paper | DOI: 10.1016/j.tice.2016.02.005

S.E. Dubowsky, B. Deutsch, R. Bhargava, B. J. McCall “Infrared emission spectroscopy of atmospheric-pressure ball plasmoids” J. Molecular Spectroscopy 322, 1-8 (2016).
Paper | DOI: 10.1002/smll.201670216

S.K. Misra, P. Mukherjee, A. Ohoka, A. S. Schwartz-Duval, S. Tiwari, R. Bhargava, D. Pan “Vibrational spectroscopy and imaging for concurrent cellular trafficking of co-localized doxorubicin and deuterated phospholipid vesicles” Nanoscale 8, 2826-2831 (2016).
Paper | DOI: 10.1039/C5NR07975F

F.N. Pounder, R.K. Reddy, R. Bhargava “Development of a practical spatial-spectral analysis protocol for breast histopathology using Fourier transform infrared spectroscopic imaging” Faraday Discussions 187, 43-68 (2016).
Paper | DOI: 10.1039/C5FD00199D

F. Ostadhossein, S. K. Misra, P. Mukherjee, A. Ostadhossein, E. Daza, S. Tiwari, S. Mittal, M. Gryka, R. Bhargava, D. Pan “Defined Host-Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer” Small In Press (2016).
Paper | DOI: 10.1002/smll.201601161

M. Pool, R. Bhargava, P.A. Jensen, K. Jensen “Work in progress: Reviving a transport phenomena course by incorporating simulation and laboratory experiences” ASEE Annual Conference and Expo (2016). [Conference Paper]

M. Pool, R. Bhargava, P.S. Carney, D. Pan, A.M. Smith “Implementing a challenge-inspired undergraduate experience” ASEE Annual Conference and Expo (2016). [Conference Paper]

T.P. Wrobel, J.T. Kwak, A. Kajdacsy-Balla, R. Bhargava “High-definition Fourier transform infrared spectroscopic imaging of prostate tissue” Proc. SPIE 9791, art. no. 97911D (2016). [Conference Paper]

S. Tiwari, J. Raman, V. Reddy, M. Dawson, R. Bhargava “Translation of infrared chemical imaging for cardiovascular evaluation” Proc. SPIE 9704, art. no. 97040X (2016) [Conference Paper]

R. Bhargava, I.W. Levin “A four class model for digital breast histopathology using high-definition Fourier transform infrared (FT-IR) spectroscopic imaging” Proc. SPIE 9791, art. no. 979118 (2016). [Conference Paper]