2021 to Present

2025

Chang, C.W., Bale, A., Bhargava, R. and Harley, B.A. “Glioblastoma Drives Protease-Independent Extracellular Matrix Invasion of Microglia” Materials Today Bio (2025).
Paper | DOI: 10.1016/j.mtbio.2025.101475

Edmonds, H., Mukherjee, S., Holcombe, B., Yeh, K., Bhargava, R. and Ghosh, A. “A Machine Learning-based Approach for Quantification of Protein Secondary Structures from Discrete Frequency Infrared Images” bioRxiv (2025).
Paper | DOI: 10.1101/2025.01.08.632028

2024

Oh, J.H., Falahkheirkhah, K. and Bhargava, R. “Detecting Hallucinations in Virtual Histology with Neural Precursors” arXiv preprint arXiv:2411.15060 (2024).
Paper | DOI: 10.48550/arXiv.2411.15060

Mukherjee, S.S., Maleszewski, J.J., Luthringer, D., Confer, M.P., Mittal, A., Dasari, S., McPhail, E.D., Kapa, S., Kesavadas, T., Kajdacsy-Balla, A., Kransdorf, E., Raman. J., and Bhargava, R. “Optical Spectroscopic Detection and Typing of Cardiac Amyloidosis” Circulation (2024).
Paper | DOI: 10.1161/CIRCULATIONAHA.124.06955

Oh, J.H., Falahkheirkhah, K. and Bhargava, R. “Are We Ready for Out-of-Distribution Detection in Digital Pathology?” In International Conference on Medical Image Computing and Computer-Assisted Intervention (2024).
Paper | DOI: 10.1007/978-3-031-72117-5_8

Salirrosas, O., Vega, E.A., Chirban, A.M., Harandi, H., Cohen, M., Anderson, A., Bhargava, R. and Conrad, C. “Laparoscopic total pancreatectomy after laparoscopic whipple”. Annals of Surgical Oncology (2024).
Paper | DOI: 10.1245/s10434-024-15576-3

Singh, D.K., Cong, Z., Song, Y.J., Liu, M., Chaudhary, R., Liu, D., Wang, Y., Prasanth, R., KC, R., Lizarazo, S., Akhnoukh, M., Gholamalamdari, O., Moitra, A., Jenkins, L.M., Bhargava, R., Nelson, E.R., Bortle, K. V., Prasanth, S. G., and Prasanth, K. V. “MANCR lncRNA Modulates Cell-Cycle Progression and Metastasis by Cis-Regulation of Nuclear Rho-GEF” Molecular and cellular biology (2024).
Paper | DOI: 10.1080/10985549.2024.2383773

Peyres, S., Wang, J., Hollyfield, D., Confer, M.P., Uner, N.B., Bhargava, R., Moore, J.S. and Sankaran, M. “Plasma Electrochemistry in Non-Aqueous Solvents and Application to Organic Synthesis” Electrochemical Society Meeting Abstracts 245 (2024).
Paper | DOI: 10.1149/MA2024-01241416mtgabs

Jeong, Y., Hsieh, P.H., Phal, Y., Bhargava, R. and Irudayaraj, J. “Label-Free Monitoring of Coculture System Dynamics: Probing Probiotic and Cancer Cell Interactions via Infrared Spectroscopic Imaging” Analytical Chemistry (2024).
Paper | DOI: 10.1021/acs.analchem.4c00894

Hur, S.W., Kwon, M., Manoharaan, R., Mohammadi, M.H., Samuel, A.Z., Mulligan, M.P., Hergenrother, P.J. and Bhargava, R. “Capturing cell morphology dynamics with high temporal resolution using single-shot quantitative phase gradient imaging” Journal of biomedical optics (2024).
Paper | DOI: 10.1117/1.JBO.29.S2.S22712

Iyer, R.R., Applegate, C.C., Arogundade, O.H., Bangru, S., Berg, I.C., Emon, B., Porras-Gomez, M., Hsieh, P.H., Jeong, Y., Kim, Y., Knox, H.J., Moghaddam, A.O., Renteria, C.A., Richard, C., Santaliz-Casiano, A., Sengupta, S., Wang, J., Zambuto, S.G., Zeballos, M.A., Pool, M., Bhargava, R., and Gaskins, H.R. ” Inspiring a convergent engineering approach to measure and model the tissue microenvironment” Heliyon (2024).
Paper | DOI: 10.1016/j.heliyon.2024.e32546

Balraj, K., Ramteke, M., Mittal, S., Bhargava, R. and Rathore, A.S. “MADR-Net: multi-level attention dilated residual neural network for segmentation of medical images” Scientific Reports (2024).
Paper | DOI: s41598-024-63538-2

Lin, H., Falahkheirkhah, K., Kindratenko, V. and Bhargava, R. “INSTRAS: INfrared Spectroscopic imaging-based TRAnsformers for medical image Segmentation” Machine Learning with Applications (2024).
Paper | DOI: 10.1016/j.mlwa.2024.100549

Sivaguru, M., Mori, S., Fouke, K.W., Ajijola, O.A., Shivkumar, K., Samuel, A.Z., Bhargava, R. and Fouke, B.W. “Osteopontin stabilization and collagen containment slows amorphous calcium phosphate transformation during human aortic valve leaflet calcification” Scientific Reports (2024).
Paper | DOI: s41598-024-62962-8

Salirrosas, O., Kawahara, W., Vega, E. A., Bhargava, R., Salehi, O., and Conrad, C. “ASO Author Reflections: Lymph Node Station 16 Status—Becoming a Student of Your Patients’ Cancer” Annals of Surgical Oncology (2024).
Paper | DOI: 10.1245/s10434-024-15099-x

Kenkel, S., and Bhargava, R. “Modeling the Thermoelastic Sample Response for Subdiffraction Infrared Spectroscopic Imaging” Chemical & Biomedical Imaging (2024).
Paper | DOI: 10.1021/cbmi.4c00018

Confer, M.P., Falahkheirkhah, K., Surendran, S., Sunny, S.P., Yeh, K., Liu, Y.T., Sharma, I., Orr, A.C., Lebovic, I., Magner, W.J., Sigurdson, S.L., Aguirre, A., Markiewicz, M.R., Suresh, A., Hicks, W.L., Birur, P., Kuriakose, M.A., and Bhargava, R. “Rapid and Label-Free Histopathology of Oral Lesions Using Deep Learning Applied to Optical and Infrared Spectroscopic Imaging Data” Journal of Personalized Medicine (2024).
Paper | DOI: 10.3390/jpm14030304

Bale, A. A., Bhargava, R., and Harley, B. “Abstract B052: Hyaluronic acid influences amino acid metabolism in glioblastoma’s U87-MG cell line in a 2D culture via LAT1 transporter expression” Cancer Research (2024).
Paper | DOI: 10.1158/1538-7445.BRAIN23-B052

Chen, J., Laverty, D.J., Talele, S., Bale, A., Carlson, B.L., Porath, K.A., Bakken, K.K., Burgenske, D.M., Decker, P.A., Vaubel, R.A., Eckel-Passow, J.E., Bhargava, R., Lou, Z., Hamerlik, P., Harley, B., Elmquist, W.F., Nagel, Z.D., Gupta, S.K., and Sarkaria, J.N. “Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization” Science translational medicine (2024).
Paper | DOI: 10.1126/scitranslmed.adj5962

Ran, J., El-Kebir, H., Lee, Y., Chamorro, L.P., Berlin, R., Aguiluz Cornejo, G.M., Benedetti, E., Giulianotti, P.C., Bhargava, R., Bentsman, J. and Ostoja-Starzewski, M. “Heat conduction in live tissue during radiofrequency electrosurgery” Journal of the Royal Society Interface (2024).
Paper | DOI: 10.1098/rsif.2023.0420

Bale, A. A., Thammineni, S., Bhargava, R., and Harley, B. “Hyaluronic Acid Influences Amino Acid Metabolism via Differential L‐Type Amino Acid Transporter 1 Expression in the U87‐Malignant Glioma Cell Line” Advanced NanoBiomed Research (2024).
Paper | DOI: 10.1002/anbr.202400107

Siddiqui, A. R., N’Diaye, J., Santiago-Carboney, A., Martin, K., Bhargava, R., and Rodríguez-López, J. “Spectroelectrochemical determination of thiolate self-assembled monolayer adsorptive stability in aqueous and non-aqueous electrolytes” Analyst (2024).
Paper | DOI: 10.1039/D4AN00241E

2023

Zakomirnyi, V.I., Moroz, A., Bhargava, R. and Rasskazov, I.L. “Large fluorescence enhancement via lossless all-dielectric spherical mesocavities” ACS nano (2023)
Paper | DOI: 10.1021/acsnano.3c09777

Holcombe, B., Foes, A., Banerjee, S., Yeh, K., Wang, S.H.J., Bhargava, R. and Ghosh, A. “Intermediate Antiparallel β Structure in Amyloid β Plaques Revealed by Infrared Spectroscopic Imaging” ACS Chemical Neuroscience (2023)
Paper | DOI: 10.1021/acschemneuro.3c00400

Patil, S. S., Ramteke, M., Verma, M., Seth, S., Bhargava, R., Mittal, S., and Rathore, A. S. “A Domain-Shift Invariant CNN Framework for Cardiac MRI Segmentation Across Unseen Domains” Journal of Digital Imaging (2023).
Paper | DOI: 10.1007/s10278-023-00873-2

Falahkheirkhah, K., Mukherjee, S.S., Gupta, S., Herrera-Hernandez, L., McCarthy, M.R., Jimenez, R.E., Cheville, J.C. and Bhargava, R “Accelerating cancer histopathology workflows with chemical imaging and machine learning” Cancer Research Communications (2023)
Paper | DOI: 10.1158/2767-9764.CRC-23-0226

Yeh, K., Sharma, I., Falahkheirkhah, K., Confer, M.P., Orr, A.C., Liu, Y.T., Phal, Y., Ho, R.J., Mehta, M., Bhargava, A. Mei, W., Cheng, G., Cheville, J.C., Bhargava, R. “Infrared spectroscopic laser scanning confocal microscopy for whole-slide chemical imaging” Nature communications (2023)
Paper | DOI: s41467-023-40740-w

Mukherjee, S. S. and Bhargava, R. “Phasor Representation Approach for Rapid Exploratory Analysis of Large Infrared Spectroscopic Imaging Data Sets” Analytical Chemistry (2023).
Paper | DOI: 10.1021/acs.analchem.3c01539

Bhargava, R. “Digital Histopathology by Infrared Spectroscopic Imaging” Annual Review of Analytical Chemistry (2023).
Paper | DOI: 10.1145/annurev-anchem-101422-090956

Wang, J., Üner, N. B., Dubowsky, S. E., Confer, M. P., Bhargava, R., Sun, Y., Zhou, Y., Sankaran, R. M., and Moore, J. S. “Plasma Electrochemistry for Carbon–Carbon Bond Formation via Pinacol Coupling” Journal of the American Chemical Society (2023).
Paper | DOI: 10.1021/jacs.3c01779

Zakomirnyi, V.I., Moroz, A., Bhargava, R. and Rasskazov, I.L “Surprisingly large fluorescence enhancements via lossless all-dielectric spherical mesocavities” arXiv (2023).
Paper | DOI: 10.48550/arXiv.2301.10899

K. Falahkheirkhah, S. Tiwari, K. Yeh, S. Gupta, L. H. Hernandez, M. R. McCarthy, R. E. Jimenez, J. C. Cheville, and R. Bhargava “Deepfake Histologic Images for Enhancing Digital Pathology” Laboratory Investigation (2023).
Paper | DOI: 10.1021/acs.analchem.2c04554

2022

P.H. Hsieh, Y. Phal, K. V. Prasanth, and R. Bhargava “Cell Phase Identification in a Three-Dimensional Engineered Tumor Model by Infrared Spectroscopic Imaging” Analytical Chemistry (2022).
Paper | DOI: 10.1016/j.labinv.2022.100006

S. Kenkel, M. Gryka, L. Chen, M. P. Confer, A. Rao, S. Robinson, K. V. Prasanth, and R. Bhargava “Chemical imaging of cellular ultrastructure by null-deflection infrared spectroscopic measurements” PNAS (2022).
Paper | DOI: 10.1073/pnas.2210516119

Y. Phal, L. Pfister, P. S. Carney, and R. Bhargava “Resolution Limit in Infrared Chemical Imaging” The Journal of Physical Chemistry C (2022).
Paper | DOI: 10.1021/acs.jpcc.2c00740

K. Falahkheirkhah, T. Guo, M. Hwang, P. Tamboli, C.G. Wood, J.A. Karam, K. Sircar, and R. Bhargava “A generative adversarial approach to facilitate archival-quality histopathologic diagnoses from frozen tissue sections” Laboratory Investigation (2022).
Paper | DOI: 10.1038/s41374-021-00718-y

S. Tiwari, K. Falahkheirkhah, G. Cheng, and R. Bhargava “Colon Cancer Grading Using Infrared Spectroscopic Imaging-Based Deep Learning” Applied Spectroscopy (2022).
Paper | DOI: 10.1177/00037028221076170

S. Mittal, J. Kim, and R. Bhargava “Statistical Considerations and Tools to Improve Histopathologic Protocols with Spectroscopic Imaging” Applied Spectroscopy (2022).
Paper | DOI: 10.1177/00037028211066327

R. J. Ho, Y. Phal, L. Lux, and R. Bhargava “Exploring the Study of miR-1301 Inhibiting the Proliferation and Migration of Squamous Cell Carcinoma YD-38 Cells through PI3K/AKT Pathway under Deep Learning Medical Images” Computational Intelligence and Neuroscience (2022).
Paper | DOI: 10.1155/2022/5865640

2021

K. Falahkheirkhah, K. Yeh, S. Mittal, L. Pfister, and R. Bhargava “Deep learning-based protocols to enhance infrared imaging systems” Chemometrics and Intelligent Laboratory Systems (2021). [Special Issue]
Paper | DOI: 10.1016.j.chemolab.2021.104390

E. Zimmerman*, S. Mukherjee*, K. Falahkheirkhah, M. Gryka, A. Kajdacsy-Balla, W. Hasan, G. Giraud, F. Tibayan, J. Raman, and R. Bhargava “Detection and Quantification of Myocardial Fibrosis Using Stain-Free Spectroscopic Imaging” Archives of Pathology & Laboratory Medicine (2021). [*Joint First Author]
Paper | DOI: 10.5858/arpa.2020-0635-OA

Y. Phal, K. Yeh, and R. Bhargava “EXPRESS: Design Considerations for Discrete Frequency Infrared Microscopy Systems” Applied Spectroscopy (2021).
Paper | DOI: 10.1177/00037028211013372

S. Mittal, T. Wrobel, M. Walsh, A. Kajdacsy-Balla, and R. Bhargava “Breast cancer histopathology using infrared spectroscopic imaging: The impact of instrumental configurations” Clinical Spectroscopy (2021).
Paper | DOI: 10.1016/j.clispe.2021.100006

K. Falahkheirkhah, and R. Bhargava “Enhancing hyperspectral imaging” Nature Machine Intelligence (2021).
Paper | DOI: 10.1038/s42256-021-00336-9

S. Tiwari, A. Kajdacsy-Balla, J. Whiteley, G. Cheng, S. Hewitt, and R. Bhargava “INFORM: INFrared-based ORganizational Measurements of tumor and its microenvironment to predict patient survival” Science Advances (2021).
Paper | DOI: 10.1126/sciadv.abb8292