2021

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Paper - Breast cancer histopathology using infrared spectroscopic imaging: The impact of instrumental configurations

February 27, 2021

In this study, we examine the role of spatial-spectral tradeoffs in infrared spectroscopic imaging configurations for probing tumors and the associated microenvironment profiles at different levels of model complexity. We image breast tissue using standard and high-definition Fourier Transform Infrared (FT-IR) imaging and systematically examine the localization, spectral origins, and utility of data for classification.p> Read Article

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Rohit Bhargava named OSA 2021 Ellis R. Lippincott Award receipient

February 15, 2021

Bioengineering founder professor Rohit Bhargava was selected as the 2021 recipient of The Optical Society (OSA) Ellis R. Lippincott Award. Co-presented by the OSA, the Coblentz Society and the Society for Applied Spectroscopy (SAS), this award recognizes significant innovations in the field of vibrational spectroscopy.

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Paper - INFORM: INFrared-based ORganizational Measurements of tumor and its microenvironment to predict patient survival

February 3, 2021

We present a high-definition infrared imaging–based organizational measurement framework (INFORM) that leverages intrinsic chemical contrast of tissue to label unique components of the tumor and its microenvironment. Using objective and automated computational methods, further, we determine organization characteristics important for prediction.

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2020

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Paper - Concurrent Vibrational Circular Dichroism Measurements with Infrared Spectroscopic Imaging

Dec 15, 2020

This study offers some insight into future possibilities of examining small, localized changes in tissue that have major implications for systemic diseases and their progression, while also laying the groundwork for additional modeling and validation in advancing the capability of VCD spectroscopy and imaging.

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Bioengineering professor Rohit Bhargava named a 2020 AAAS Fellow

Nov 24, 2020

Every year, AAAS fellows are elected by their peers who recognize each fellow for his or her important contribution to the STEM field through pioneering research, teaching, collaborations and advancing public understanding of science. Bhargava and the four Illinois researchers have joined the ranks of distinguished AAAS fellows.

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Paper - Freeform Three-Dimensionally Printed Microchannels via Surface-Initiated Photopolymerization Combined with Sacrifical Molding

Oct 22, 2020

The combination of surface-initiated photopolymerization and freeform 3D printing has potential to fabricate physiologically relevant structures useful for a variety of tissue engineering and biomedical applications.

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Paper - Infrared Optical Hybrid (IR-OH) Microscopy for Label-Free Histopathology

Sept 14, 2020

We have developed a solution that enables large area mid-IR photothermal imaging of tissue sections at high quality and high speed and introduced its application to histopathology and automated disease with artificial intelligence.

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Paper - Closed-loop atomic force microscope-infrared spectroscopic imaging for nanoscale imaging for nanoscale molecular characterization

Jun 26, 2020

The group has improved signal-to-noise ratio on a previously published AFM-IR via a theoretical model to clarify the source of the noise. Instead of detecting cantilever deflection, researchers use a piezo component as a stage to maintain zero deflection. This technique has promising applications on observing small and complex mixtures.

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Yamuna Phal receives Nadine Barrie Smith Memorial Fellowship

May 11, 2020

Yamuna Phal was named one of the twelve recipents in 2020 Beckman Institue spring student awards based on prominent research experience. Yamuna's research focuses on improving diagnostic capability in nowdays technology by the integration of IR spectroscopic imaging system and polarimetric measurements.

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Dr. Rohit Bhargava honors with 2020 Outstanding Advising Awards

April 10, 2020

Dr. Bhargava received 2020 Outstanding Advising Awards, nominated by students. "Dr. Bhargava always shows passion and willingness on guiding students to the best path and being supportive throughout the process." said by a sophomore student in Bioengineering.

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Paper - Digital Assessment of Stained Breast Tissue Images for Comprehensive Tumor and Microenvironment Analysis

February 18, 2020

The group develops an IR-optical hybrid (IR-OH) microscope and synergize with the emerging computational ubiquity to handle the wide palette of IR molecular contrast. The combined features from different aspects create changes on how we handle tissue structure by enabling all-digital pathology with applications across the spectrum of biomedical science. Read the full article below.

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Shachi Mittal wins Tomas B. Hirschfield scholar award

October 2, 2019

Shachi Mittal has won Tomas B. Hirschfield scholar award in SciX2020. Her outstanding works on early cancer detection and prognostic assssment are recognized. She utilizes spectroscopy data to develop efficient computational models and link to clinical translation. Besdies research, she has mentored several students by assisting them to develop research skill.

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Dr. Rohit Bhargava is invited as a keynote speaker in SciX2019

October 13, 2019

Dr. Rohit Bhargava has delivered a keynote presentation in SciX2019, the annual meeting of the Federation of Analytical Chenistry and Spectroscopy Societies (FACSS). He talked about how a great exchange has been made by the convergence of measurement and data sciences.

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Saumya Tiwari wins award at SciX2019

October 15, 2019

Saumya Tiwari recieved the Society for Applied Spectroscopy’s (SAS) Barbara Stull Graduate Student Award at SciX2019 based on her brillant work. Her research focuses on developing spectroscopic imaging to determine patients outsomes in colon cancer. She also works on computational models for spectroscopic imaging data analysis.

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2019

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Paper - Digital Assessment of Stained Breast Tissue Images for Comprehensive Tumor and Microenvironment Analysis

October 2, 2019

Collaborators between the University of Illinois at Urbana-Champaign, University of Craiova (Romania) and University of Illinois at Chicago published this paper, led by Dr. Shachi Mittal, focused on using interpretable features from deep learning methods to categorize breast cancer. Read the full article below.

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Sudipta Mukherjee wins award for 2019 Beckman Image Research Contest

September 23, 2019

Sudipta Mukherjee won an award for the 2019 Beckman Image Research Contest. The winning image is acquired using stimulated Raman scattering microscope and shows a co-culture of colon cancer cells and fibroblasts embedded in hydrogel matrix.

2019 Beckman Image Research Contest
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Paper - Extended Multiplicative Signal Correction for Infrared Microspectroscopy of Heterogeneous Samples with Cylindrical Domains

June 01, 2019

Drs. Ilia Rasskazov, Rajveer Singh, Scott Carney, and Rohit Bhargava published on looking at optical scattering corrections with a goal to have an absorption spectrum relatively free of sample morphology effects. Read the Paper below.

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Paper - A fully automated, faster noise rejection approach to increasing the analytical capability of chemical imaging for digital histopathology

April 24, 2019

Collaborators between the University of Illinois at Urbana-Champaign, University of Illinois Chicago, and the University of Texas at Austin published this paper focusing on denoising images against the Minimum Noise Fraction (MNF).Read the Paper below.

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Paper - Relating strain hardening moduli in high density polyethylene copolymers to anisotropic molecular deformation using infrared spectroscopic imaging

April 16, 2019

The second latest paper co-authored with Chevron Phillips Chemical Company focuses on bulk strain hardening moduli of tensile polyolefin samples. Read the full article below.

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5 Amazing Projects That Will Change the Future of Healthcare

March 11, 2019

Dr. Rohit Bhargava's 3D printer work was featured in PCMag as one of the five amazing projects that will change the future of healthcare. Read the full article below.

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2019 Beckman Open House

March 09, 2019

The Chemical Imaging and Structures Laboratory particpated in the biannual Beckman Open House on Friday, March 8 and Saturday, March 9. Visitors had the opportunity to build chemical structures out of marshmallows, learn about spectroscopy, and even have the chance to win a free-form 3D printed item!

Beckman Open House
New article

Paper - comparison of mid-infrared spectral regions on accuracy of tissue classification

March 06, 2019

Shachi Mittal and Dr. Bhargava's paper on IR Spectroscopy dives deeper into spectral regions that can provide high-accuracy classifiers other than just the fingerprint region. Read the full article below.

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Shachi Mittal Selected as Beckman Fellow

March 01, 2019

Shachi Mittal were among the five researchers named as Beckman Institute Postdoctoral Fellows for 2019. Shachi expects to earn her Ph.D. in bioengineering in 2019. She hopes to improve the treatment of breast cancer by developing digital models using molecular imaging. Her work could provide more detailed diagnoses, identify breast cancer subtypes, and better predict patient outcomes for improved patient care.

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Rohit Bhargava does podcast on Cancer

Campus Conversation: Rohit Bhargava of Cancer Center at Illinois

February 07, 2019

Cancer Center Director Rohit Bhargava featured in the News Gazette Campus Conversation podcast and talked about the center's plans and impact both on campus and in the community.

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Paper - Controlled Dissolution of Freeform 3D Printed Carbohydrate Glass Scaffolds

January 22, 2019

"Controlled Dissolution of Freeform 3D Printed Carbohydrate Glass Scaffolds in Hydrogels Using a Hydrophobic Spray Coating" was published in Additive Manufacturing late last year and focuses on sacrificial molding to generate complex 3D models. Read the full article below.

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